“We are deeply concerned about the Russian invasion of Ukraine and stand with all the people suffering as a result of the violence,” the company said in a statement.
“We support humanitarian endeavours, provide assistance to the crumbling refugee crisis, and are doing everything we can to support our team in the region,” she added.
Apple outlined a number of steps in response to the war, including halting all exports to its sales channels in Russia.
The company said Apple Pay and other services were being restricted.
On Tuesday, users in Russia were still able to access the Apple Store online, but attempts to purchase iPhones showed that they were not available for delivery.